4 Simple Steps to administration in less than 1 minute7

Step 1: Reconstitute

  • Add 5 mL of sterile water for injection (without bacteriostatic agent)7

Step 2: Shake

  • Shake vial to ensure an orange-colored uniform suspension7*
    • Should take approximately 10 seconds1

Step 3: Fill syringe

  • Visually inspect the vial for particulate matter and discoloration prior to administration7
  • Draw the appropriate dose of the reconstituted suspension into the syringe

Step 4: Administer

  • RYANODEX® should be administered by intravenous push7

*Must use the contents of the vial within 6 hours after reconstitution. Store reconstituted suspensions at controlled room temperature (68°F to 77°F or 20°C to 25°C).7

Dosage in adults and pediatrics7

Administer RYANODEX® by intravenous push at a minimum dose of 1 mg/kg. If the physiologic and metabolic abnormalities of MH continue, administer intravenous pushes up to the maximum cumulative dosage of 10 mg/kg. If the physiologic and metabolic abnormalities reappear, repeat RYANODEX® dosing by intravenous push starting with 1 mg/kg.

MHAUS recommends initial and repeat treatment doses of 2.5 mg/kg8


  • The recommended prophylactic dose of RYANODEX® is 2.5 mg/kg administered intravenously over a period of at least 1 minute, starting approximately 75 minutes prior to surgery. Avoid agents that trigger MH
  • Precautions should be taken when administering RYANODEX® preoperatively for the prevention of malignant hyperthermia, including monitoring vital signs, avoiding known triggering agents, and monitoring for early clinical and metabolic signs of malignant hyperthermia that may indicate additional treatment is needed
  • If surgery is prolonged, administer additional individualized RYANODEX® doses during anesthesia and surgery

Indication and Important Safety Information