Reconstituting and administering dantrolene sodium in an MH crisis is fast and easy with RYANODEX® (dantrolene sodium) for injectable suspension.1,2 With fewer vials and less fluid required for a loading dose, compared to other dantrolene sodium IV products, RYANODEX® allows for fast administration of medication to reduce treatment delays.1,9,10


Fast reconstitution and administration

Watch how to quickly and easily reconstitute and administer RYANODEX® in the event of an MH crisis.


  • Less than 1 minute for reconstitution and administration of a loading dose (2.5 mg/kg) of dantrolene sodium in an MH crisis1,3
    • Fewer vials required to treat MH (1 vial contains 250 mg of dantrolene sodium)1,9,10
    • 1 vial of RYANODEX® contains the same amount of dantrolene sodium for injection as 12.5 vials of other dantrolene sodium formulations
  • Over 99% less sterile water for injection than other dantrolene sodium IV treatments1,9,10
  • 1 vial provides a loading dose for patients up to 100 kg2,3
    • Can be reconstituted and administered by 1 healthcare provider (eg, an anesthesia provider)
RYANODEX®1 Other treatment protocols9,10
1 to 3 vials 12.5 to 36 vials
5 mL to 15 mL of sterile water 750 mL to 2160 mL of sterile water
Less than 1 minute for reconstitution and administration >15 minutes11
1 staff member2 1 to 3 staff members2
250 mg dantrolene sodium per vial 20 mg dantrolene sodium per vial
50 mg/mL reconstituted formulation concentration 0.33 mg/mL reconstituted formulation concentration

How to reconstitute RYANODEX®

Each 250 mg vial of RYANODEX® should be reconstituted by adding 5 mL of sterile water for injection USP (without a bacteriostatic agent), and the vial should be shaken to ensure an orange colored uniform suspension. Five percent dextrose injection USP, 0.9% sodium chloride injection USP, and other acidic solutions are not compatible with RYANODEX® and should not be used. The contents of the vial must be used within 6 hours after reconstitution. Store reconstituted suspensions at controlled room temperature (68°F to 77°F or 20°C to 25°C).1

Administering RYANODEX®

RYANODEX® should be administered by intravenous push. RYANODEX® can be administered either into the intravenous catheter while an intravenous infusion of 0.9% sodium chloride injection, or 5% dextrose injection is freely running; or into the indwelling catheter–after assuring its patency–without a freely running infusion. Flush the line to assure that there is no residual RYANODEX® remaining in the catheter.