RYANODEX Dantrolene Sodium | Keep Cool in a Crisis

RYANODEX^®: Keep cool in the crisis with administration in less than 1 minute

Reformulated version of dantrolene sodium utilizes innovative nanosuspension technology for an improved performance in treating MH¹
Loading dose (2.5 mg/kg) of dantrolene sodium can be reconstituted and administered in less than 1 minute in an MH crisis along with other appropriate supportive measures^2,3
1 vial of RYANODEX^® (dantrolene sodium) for injectable suspension contains the same amount of dantrolene sodium as 12.5 vials of other approved dantrolene sodium formulations^1,9,10
1 anesthesia provider can administer RYANODEX^®, helping the entire patient care team stay cool in the crisis²
The use of RYANODEX^® in the treatment of an MH crisis is not a substitute for implementing supportive measures

Important Safety Information

RYANODEX^® is not a substitute for appropriate supportive measures in the treatment of malignant hyperthermia (MH), including discontinuing use of MH-triggering anesthetic agents, managing the metabolic acidosis, instituting cooling when necessary, and administering diuretics to prevent late kidney injury due to myoglobinuria (the amount of mannitol in RYANODEX^® is insufficient to maintain diuresis).

RYANODEX^® is associated with skeletal muscle weakness such as loss of grip strength and weakness in the legs, as well as drowsiness, dizziness, dysphagia, dyspnea, and decreased inspiratory capacity. Patients should not be permitted to ambulate without assistance until they have normal strength and balance. Care must be taken to prevent extravasation of RYANODEX^® into the surrounding tissue due to the high pH of the reconstituted RYANODEX^® suspension and potential for tissue necrosis.

Cool in a Crisis

RYANODEX®: Keep cool in the crisis with administration in less than 1 minute

Important Safety Information

Indications

Important Safety Information

RYANODEX^®: Keep cool in the crisis with administration in less than 1 minute